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Prognostic factors in patients with malignant pleural effusion: Is it possible to predict mortality in patients with

Fernando Conrado Abrao1, Renata D'Alpino Peixoto2, Igor Renato Louro Bruno de Abreu1

  • 1Department of Thoracic Surgery of Hospital São José, São Paulo, Brazil.

Journal of Surgical Oncology
|January 12, 2016
PubMed
Abstract

Insights

Predictors of mortality in malignant pleural effusion (MPE) patients with good performance status were identified. Gastrointestinal primary site, low pleural fluid albumin, and high neutrophil-to-lymphocyte ratio (NLR) were associated with increased mortality risk.

Area of Science:

  • Oncology
  • Palliative Care
  • Thoracic Surgery

Background:

  • Malignant pleural effusion (MPE) impacts patient prognosis.
  • Identifying mortality predictors in MPE patients with good performance status is crucial for guiding palliative care.
  • Patients undergoing pleural palliative procedures require accurate prognostic information.

Purpose of the Study:

  • To determine predictors of mortality in patients with MPE and good performance status (ECOG 0-2) undergoing palliative procedures.
  • To identify factors influencing survival in this specific patient group.

Main Methods:

  • Prospective study of 64 MPE patients undergoing pleural palliative procedures (2013-2014).
  • Patients classified by Eastern Cooperative Oncology Group (ECOG) performance status (0-2).
  • Prognostic factors analyzed using Kaplan-Meier and multivariable Cox regression models.

Main Results:

  • Gastrointestinal primary malignancy was significantly associated with mortality (P=0.006).
  • Low albumin concentration in pleural fluid correlated with increased mortality risk (P=0.017).
  • High serum neutrophil-to-lymphocyte ratio (NLR) was a significant predictor of mortality (P=0.007).

Conclusions:

  • Gastrointestinal origin of MPE, low pleural fluid albumin, and high NLR are significant mortality predictors in ECOG 0-2 patients.
  • These findings can aid in selecting optimal palliative interventions for MPE patients.
  • Prognostic factor identification supports personalized palliative care strategies.
Keywords:
malignantpalliative carepleurapleural effusionsurvival

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