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Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
Published on: December 19, 2014
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Primary Larynx Cryptococcus neoformans Infection: A Distinctive Clinical Entity
Mathieu Bergeron1, Andrée-Anne Gagné1, Mathieu Côté2
1Laval University .
Open Forum Infectious Diseases
|January 12, 2016
Summary
Cryptococcus neoformans can infect vocal cords, presenting similar to other infiltrative diseases. Diagnosis requires tissue biopsy, and treatment with fluconazole for at least six weeks is recommended.
Area of Science:
- Mycology
- Otolaryngology
- Infectious Diseases
Background:
- Cryptococcus neoformans is an opportunistic fungal pathogen.
- Vocal cord infections are rare but possible.
- Inhaled corticosteroids are a known risk factor for opportunistic infections.
Purpose of the Study:
- To describe the clinical presentation and diagnostic challenges of Cryptococcus neoformans infection of the vocal cords.
- To determine the efficacy of antifungal treatment for this condition.
Main Methods:
- Case report and literature review.
- Diagnostic procedures included endoscopy and tissue biopsy.
- Treatment involved oral fluconazole.
Main Results:
- Endoscopic findings were non-specific, mimicking other infiltrative lesions.
- Tissue biopsy confirmed Cryptococcus neoformans infection.
- A minimum treatment course of fluconazole 400 mg daily for 6 weeks was effective.
Conclusions:
- Vocal cord cryptococcosis should be considered in patients with risk factors, especially those using inhaled corticosteroids.
- Tissue biopsy is crucial for accurate diagnosis.
- Aggressive antifungal therapy is necessary for a successful outcome.
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