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Related Experiment Video

Updated: Mar 27, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Optic Perineuritis.

Simon J Hickman1

  • 1Department of Neurology, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK. simon.hickman@sth.nhs.uk.

Current Neurology and Neuroscience Reports
|January 13, 2016
PubMed
Summary
This summary is machine-generated.

Optic perineuritis (OPN) is an inflammatory condition affecting the optic nerve sheath. This review synthesizes current knowledge on idiopathic and secondary OPN, offering guidance on diagnosis and treatment.

Keywords:
CorticosteroidsGadoliniumMagnetic resonance imagingOptic perineuritisVision

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Area of Science:

  • Ophthalmology
  • Neurology
  • Immunology

Background:

  • Optic perineuritis (OPN) is defined as idiopathic orbital inflammatory disease targeting the optic nerve sheath.
  • OPN can be idiopathic or associated with systemic inflammatory conditions.
  • It is a rare disorder with limited data from case reports and small series.

Purpose of the Study:

  • To review and synthesize recent literature on idiopathic and secondary OPN.
  • To discuss the current understanding of OPN presentation and management.
  • To provide recommendations for investigating and treating OPN.

Main Methods:

  • Literature review of recent articles on optic perineuritis.
  • Synthesis of information on idiopathic and secondary OPN.
  • Analysis of case reports and small case series.

Main Results:

  • Recent literature expands understanding of OPN's idiopathic and secondary forms.
  • Case reports and series provide insights into OPN's clinical spectrum.
  • Evidence-based suggestions for OPN investigation and treatment are emerging.

Conclusions:

  • Optic perineuritis requires further research due to its rarity.
  • A comprehensive approach is needed for diagnosing and managing OPN.
  • This review consolidates current knowledge and proposes future directions.