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Related Experiment Videos

[Cimetidine and creatinine clearance].

N V Olsen, S D Ladefoged, B F Feldt-Rasmussen

    Ugeskrift for Laeger
    |August 28, 1989
    PubMed
    Summary
    This summary is machine-generated.

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    Cimetidine reduces creatinine secretion in renal transplant patients, lowering renal creatinine clearance (CKrea) without affecting glomerular filtration rate (GFR). This impacts graft function assessment using CKrea alone.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Transplantation

    Context:

    • Cimetidine is known to reduce renal tubule creatinine secretion in healthy individuals and those with chronic kidney disease.
    • The effect of cimetidine on renal function in renal transplant recipients was previously uncharacterized.

    Purpose:

    • To investigate the effect of cimetidine on endogenic creatinine clearance (CKrea) and glomerular filtration rate (GFR) in patients with renal transplants.

    Summary:

    • Renal clearance of endogenic creatinine (CKrea) was measured before and after intravenous cimetidine administration in nine renal transplant patients.
    • CKrea decreased by 29% (median 65 to 46 ml/min, p < 0.01), while GFR, assessed by 125I-thalamate clearance (CTh), remained unchanged.
    • Fractionated creatinine clearance (CKrea/CTh) significantly decreased from 1.43 to 1.03 (p < 0.01).

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    Impact:

    • Cimetidine administration leads to reduced creatinine secretion in renal transplant recipients.
    • This finding is crucial for accurate assessment of renal graft function, as relying solely on CKrea may be misleading.
    • Clinical practice should consider cimetidine's effect when interpreting renal function tests in transplant patients.