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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Mantle Cell Lymphoma.

Chan Yoon Cheah1, John F Seymour1, Michael L Wang2

  • 1Chan Yoon Cheah, Sir Charles Gairdner Hospital and PathWest Laboratory Medicine WA, Nedlands; Chan Yoon Cheah, University of Western Australia, Crawley, Western Australia; John F. Seymour, Peter MacCallum Cancer Centre, East Melbourne; John F. Seymour, University of Melbourne, Parkville, Victoria, Australia; and Chan Yoon Cheah and Michael L. Wang, The University of Texas MD Anderson Cancer Center, Houston, TX.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|January 13, 2016
PubMed
Summary
This summary is machine-generated.

Mantle cell lymphoma (MCL) treatment has advanced significantly. New targeted therapies and improved chemoimmunotherapy offer better outcomes for patients with this rare non-Hodgkin lymphoma.

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Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Mantle cell lymphoma (MCL) is a rare non-Hodgkin lymphoma subtype with a historically poor prognosis.
  • Significant therapeutic advances occurred in the early 21st century, including high-dose therapy with autologous stem-cell rescue and high-dose cytarabine for younger patients, and maintenance rituximab and bendamustine for older patients.

Purpose of the Study:

  • To review recent advancements in MCL biology and understanding.
  • To outline a recommended therapeutic approach for MCL based on current clinical trial data.

Main Methods:

  • Synthesis of data from published clinical trials.
  • Review of molecular pathophysiology and targeted therapies.

Main Results:

  • Understanding MCL molecular pathophysiology has led to new, effective targeted agents.
  • FDA-approved agents include bortezomib (proteasome inhibitor), lenalidomide (immunomodulator), and ibrutinib (Bruton's tyrosine kinase inhibitor).

Conclusions:

  • Therapeutic strategies for MCL have evolved with improved outcomes.
  • Recommended approaches integrate chemoimmunotherapy, stem-cell transplantation, and mechanism-based targeted therapies.