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Updated: Mar 27, 2026
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
Randomized dose-response study of subcutaneous immunotherapy with a Dermatophagoides pteronyssinus extract in
Victoria Moreno1, Marta Alvariño2, Fernando Rodríguez3
1Servicio de Alergología, Hospital Blanca Paloma, Huelva, Spain.
Aim:
To evaluate the efficacy of Dermatophagoides pteronyssinus (DPT) subcutaneous immunotherapy in allergic rhinoconjunctivitis patients.
Patients & Methods:
This 17-week double-blind study randomized 136 patients (95 evaluable) to five dose groups of DPT depot extract (0.0625-0.75 skin prick test [SPT] units) or placebo, administered in a six updosing schedule.
Results:
A dose-response was observed for clinical efficacy (allergen concentration needed to induce a positive nasal provocation test response from baseline to final visit) and safety (adverse reactions). Local and systemic reactions occurred with 14.8 and 6.4% of administered doses, respectively; a single anaphylactic reaction occurred in each of Groups 3, 4 and 5 (0.3% of doses).
Conclusion:
The risk-benefit profile appeared most favorable with a DPT dose of 0.125 SPT units.
