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Updated: Feb 6, 2026

Protein Modifications: Protein Kinases and Phosphatases

Protein Modifications: Protein Kinases and Phosphatases

A new classification for mandibular defects after oncological resection.

James S Brown¹, Conor Barry², Michael Ho³

¹Head and Neck Surgery, Aintree University Hospital, Liverpool, UK; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.

The Lancet. Oncology

|January 14, 2016

Summary

This summary is machine-generated.

A new classification system for mandibular defects after cancer surgery is proposed. This system categorizes defects based on location and extent, aiding reconstruction planning and improving outcomes.

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Protein Modifications: Protein Kinases and Phosphatases

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Covalently Linked Protein Regulators and Post-translational Modification

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Area of Science:

Oral and Maxillofacial Surgery
Oncology
Reconstructive Surgery

Background:

Currently, no standardized classification system exists for mandibular defects following oncological resection.
Existing classifications lack sufficient detail for consistent application in reconstructive surgery.

Purpose of the Study:

To review existing literature on mandibular defect classifications.
To propose a novel, anatomically based classification system for mandibular defects after oncological resection.

Main Methods:

A systematic review of 167 studies was conducted.
49 studies with sufficiently detailed defect descriptions were analyzed.
Analysis focused on classification, reconstruction methods, defect size, osteotomies, and complications.

Main Results:

A new classification system (Class I-IV, with sub-classes Ic, IIc, IVc for condylectomy) based on four mandibular landmarks (angles and canines) was developed.
The proposed classification correlates with defect size, number of osteotomies, and functional/aesthetic outcomes.

Conclusions:

The proposed classification system offers a standardized approach to categorizing mandibular defects.
This system can guide reconstructive strategies and potentially improve patient outcomes after oncological resection.