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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Serum Telomerase Levels and COPD Exacerbations.

Fulsen Bozkus1, Selma Guler2, Secıl Sımsek3

  • 1Department of Chest Diseases fulsenbatmaz@gmail.com.

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COPD exacerbation is linked to oxidative stress, indicated by an abnormal copper/zinc ratio and increased telomerase, copper, and zinc levels. This imbalance affects lung function and inflammation markers.

Keywords:
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Area of Science:

  • Biochemistry
  • Pulmonology
  • Oxidative Stress Research

Background:

  • Limited research exists on telomerase levels during COPD exacerbations.
  • Investigating biomarkers like telomerase, copper, and zinc is crucial for understanding COPD pathophysiology.

Purpose of the Study:

  • To compare lipid peroxidation, telomerase, zinc (Zn), copper (Cu), and malondialdehyde levels in COPD exacerbation patients versus asymptomatic smokers.
  • To assess the relationship between these biomarkers and respiratory function.

Main Methods:

  • Blood samples analyzed from 45 COPD exacerbation patients and 42 healthy smokers.
  • Serum levels of telomerase, malondialdehyde, Cu, and Zn were measured and compared.
  • Respiratory function tests, C-reactive protein, and sedimentation rates were assessed.

Main Results:

  • COPD exacerbation group showed a lower Cu/Zn ratio (P < .001).
  • Significantly higher telomerase, malondialdehyde, Cu, and Zn levels were observed in the COPD group (P < .001).
  • Negative correlation found between malondialdehyde, Cu, Zn, and FEV1 (P < .001); COPD group had lower FEV1/FVC and higher inflammatory markers.

Conclusions:

  • Increased telomerase, Cu, and Zn levels, along with a reduced Cu/Zn ratio, suggest oxidative stress in COPD exacerbation.
  • Abnormal lung oxidant-antioxidant balance is evident in COPD exacerbation.
  • Elevated telomerase levels are associated with this oxidative imbalance.