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Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
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Related Experiment Video

Updated: Mar 27, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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Leaky gut - concept or clinical entity?

Eamonn M M Quigley1

  • 1Division of Gastroenterology and Hepatology, Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist Hospital, Weill Cornell Medical College Houston, Houston, Texas, USA.

Current Opinion in Gastroenterology
|January 14, 2016
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Summary
This summary is machine-generated.

The gut barrier, a complex entity, plays a role in gastrointestinal disorders. While its function can be assessed, its primary role in disease progression requires further definition.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • The gut barrier is a complex, multicomponent system crucial for intestinal health.
  • It involves epithelial cells, immune responses, and interactions with luminal contents like the microbiota.

Purpose of the Study:

  • To evaluate the current status and role of the gut barrier in various gastrointestinal disorders.
  • To critically assess the interpretation and limitations of gut barrier function tests.

Main Methods:

  • Review of current literature on gut barrier function and gastrointestinal disorders.
  • Analysis of studies assessing intestinal permeability and mucosal immune responses.
  • Evaluation of the limitations of paracellular flux measurements.

Main Results:

  • Intestinal permeability is a key but limited measure of overall gut barrier function.
  • The mucosal immune response significantly influences barrier integrity.
  • Inflammation effects must be considered when interpreting permeability studies in disease.

Conclusions:

  • Assessing gut barrier function in humans requires awareness of test specificity and limitations.
  • The primacy of gut barrier dysfunction in gastrointestinal disorders remains undefined.
  • Few interventions improving barrier function have demonstrated efficacy in altering disease natural history.