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Eccrine Angiomatous Hamartoma: A Clinicopathologic Review of 18 Cases
Andrew T Patterson1, Monique G Kumar, Susan J Bayliss
1*Ohio State University College of Medicine, Columbus, OH; †Department of Dermatology, Emory University School of Medicine, Atlanta, GA; ‡Division of Dermatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO; §Division of Dermatology, Nationwide Children's Hospital, Columbus, OH; ¶Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO; and ‖Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH.
Background:
Eccrine angiomatous hamartoma (EAH) is a benign cutaneous lesion defined by the proliferation of hamartomatous eccrine and capillary-like vascular elements in the dermis. However, the epidemiologic, morphologic, and histopathologic aspects of this uncommon disorder have yet to be fully delineated.
Methods:
The authors retrospectively reviewed 18 EAH cases (including 14 accompanying skin biopsy specimens) diagnosed at 4 American university hospitals from 1996 to 2014.
Results:
Patients ranged from 3 days to 84 years at time of diagnosis with a median age of 15 years. A male:female ratio of 11:7 was observed. Sixty-seven percent of cases presented in the extremities, but lesions in the trunk and head/neck regions also occurred. Four patients had multiple lesions, and 2 displayed a segmental pattern. Histologically, dermal vascular dilatation and acanthosis often accompanied EAH's typical eccrine and vascular comingling. One individual developed EAH at the site of a recurrent squamous cell carcinoma after previous excision.
Conclusions:
Although previously thought to occur primarily as a solitary angiomatous-appearing malformation on the extremities of children, EAH may develop with some frequency in adults and may manifest in a multifocal linear distribution. The authors also raise additional histopathologic consideration in support of the vascular theory of histogenesis for this condition.
