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Related Concept Videos

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Related Experiment Video

Updated: Mar 27, 2026

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
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Genome Editing and Its Applications in Model Organisms.

Dongyuan Ma1, Feng Liu1

  • 1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Genomics, Proteomics & Bioinformatics
|January 15, 2016
PubMed
Summary

Recent advances in genome editing technologies like CRISPR/Cas offer revolutionary potential for treating genetic diseases. This review highlights CRISPR/Cas advancements and applications in research and personalized medicine.

Keywords:
CRISPR/CasDisease modelGene therapyGenome editingZebrafish

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biotechnology

Background:

  • Innovative biological research relies on technological advancements.
  • Molecular tools like zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas have revolutionized genome editing.
  • These technologies hold promise for developing effective therapeutic strategies for heritable diseases.

Purpose of the Study:

  • To review recent advancements in genome editing, with a specific focus on CRISPR/Cas technology.
  • To cover the underlying principles, technological optimization, and applications of CRISPR/Cas.
  • To discuss the use of CRISPR/Cas in model organisms, disease modeling, and gene therapy for personalized medicine.

Main Methods:

  • Review of recent scientific literature on genome editing technologies.
  • Focus on CRISPR/Cas system principles and technical improvements.
  • Analysis of CRISPR/Cas applications in various model systems and therapeutic contexts.

Main Results:

  • CRISPR/Cas technology has undergone substantial progress and wide application in recent years.
  • Significant technical improvements have been made in CRISPR/Cas systems.
  • CRISPR/Cas is increasingly applied in zebrafish and other model organisms for research and disease modeling.

Conclusions:

  • Genome editing technologies, particularly CRISPR/Cas, have revolutionized biological research and therapeutic development.
  • CRISPR/Cas offers powerful tools for disease modeling and the advancement of gene therapy for personalized medicine.
  • Continued advancements in CRISPR/Cas technology promise to further accelerate progress in treating genetic disorders.