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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Drug Toxicity: Allergic Reactions01:30

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Allergic Drug Reactions01:27

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Updated: Mar 27, 2026

Measuring Local Anaphylaxis in Mice
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Ranitidine-induced anaphylaxis: clinical features, cross-reactivity, and skin testing.

K H Park1,2, J Pai3, D-G Song4

  • 1Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|January 15, 2016
PubMed
Summary
This summary is machine-generated.

Ranitidine, though generally safe, can cause anaphylaxis. This study highlights the importance of considering ranitidine as a potential cause of severe allergic reactions, even when reintroducing the drug.

Keywords:
adverse drug reactionanaphylaxishistamine H2 receptor antagonistsranitidine

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Area of Science:

  • Pharmacovigilance
  • Allergy and Immunology
  • Drug Safety

Background:

  • Histamine H2 receptor antagonists, including ranitidine, are widely prescribed.
  • Despite a reputation for safety, ranitidine has been linked to anaphylaxis.
  • 99 cases of ranitidine-induced anaphylaxis were reported in Korea between 2007 and 2014.

Purpose of the Study:

  • To determine the incidence of ranitidine-induced anaphylaxis.
  • To characterize the clinical features of this adverse drug reaction.
  • To evaluate diagnostic methods for ranitidine-induced anaphylaxis.

Main Methods:

  • Review of ranitidine-related pharmacovigilance data from 2007-2014.
  • In vivo and in vitro studies involving 23 patients with suspected ranitidine reactions.
  • Performance of skin tests, oral provocation tests, and laboratory tests, including comparisons with other H2 receptor antagonists.

Main Results:

  • Over 7 years, 584 patients experienced adverse reactions to ranitidine, with 99 (17.0%) cases of anaphylaxis.
  • Skin prick tests were positive in 91.7% of patients with ranitidine-induced anaphylaxis at a concentration of 20 mg/mL.
  • No cross-reactivity was observed with cimetidine or proton pump inhibitors; however, 82.6% of patients experienced recurrent reactions upon ranitidine reintroduction.

Conclusions:

  • Ranitidine, despite its safety profile, can induce diverse adverse reactions, including anaphylaxis.
  • Healthcare providers should consider ranitidine as a potential cause of anaphylaxis.
  • Increased vigilance for ranitidine-related adverse reactions is warranted.