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Updated: Mar 27, 2026

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
Quantitative chirality sensing of amines and amino alcohols via Schiff base formation with a stereodynamic UV/CD
Zeus A De Los Santos1, Ransheng Ding1, Christian Wolf1
1Department of Chemistry, Georgetown University, Washington, D.C., USA. cw27@georgetown.edu.
Abstract:
A stereodynamic chemosensor that can be used for simultaneous determination of the absolute configuration, enantiomeric composition and total concentration of chiral amines and amino alcohols based on two fast optical measurements was prepared and tested. The free sensor is CD-silent and produces characteristic blue-shifted UV and CD signals upon substrate binding via Schiff base formation. The potential in high-throughput screening applications and for rational sensor developments are discussed.
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