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Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses

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Published on: November 24, 2014

HaNDL with care.

Nicholas Fernandez¹, Ruwani Wijeyekoon², Anna Richardson³

¹Postgraduate Centre, Education Centre Royal Bolton Hospital NHS Foundation Trust Minerva Rd, Farnworth, Bolton, Lancashire BL4 0JR.

|January 15, 2016

Summary

This summary is machine-generated.

Headache with neurological deficit and cerebrospinal fluid (CSF) lymphocytosis (HaNDL) syndrome requires careful diagnosis. Early consideration of HaNDL can prevent unnecessary treatments and invasive procedures.

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Area of Science:

Neurology
Internal Medicine

Background:

Headache with neurological deficit and cerebrospinal fluid (CSF) lymphocytosis (HaNDL) syndrome presents a diagnostic challenge in acute medicine.
Differential diagnoses include serious infectious, inflammatory, and neoplastic conditions.

Purpose of the Study:

To highlight the importance of considering HaNDL syndrome in relevant clinical presentations.
To emphasize the need to exclude other serious conditions before diagnosing HaNDL.

Main Methods:

Clinical case review and literature synthesis.
Diagnostic criteria for HaNDL syndrome.

Main Results:

HaNDL syndrome is characterized by headache, neurological deficits, and CSF lymphocytosis.
Exclusion of other pathologies is crucial for accurate diagnosis.

Conclusions:

Increased awareness and prompt recognition of HaNDL syndrome are essential.
Early diagnosis can avert prolonged antimicrobial therapy and unnecessary invasive investigations like cerebral angiography.