Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skeleton and Calcium Homeostasis

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

Urinary Tract Calculi V: Nursing Management

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

The Parathyroid Glands

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The history of stress hyperglycaemia.

The journal of the Royal College of Physicians of Edinburgh·2015

Same author

Screening for diabetic retinopathy--false positives do occur (it could be Shagreene).

Diabetic medicine : a journal of the British Diabetic Association·2004

Same author

A new cause of neuroglycopenia: "missing the point".

Diabetic medicine : a journal of the British Diabetic Association·2004

Same author

Withholding thrombolysis in patients with diabetes mellitus and acute myocardial infarction.

Diabetic medicine : a journal of the British Diabetic Association·1998

Same author

Hypokalaemic alkalosis.

Postgraduate medical journal·1998

Same author

Re: Basic sciences in problem-based learning and conventional curricula: students' attitudes.

Medical education·1998

Same journal

Procalcitonin use in Acute Medicine in the United Kingdom: a survey of practice, barriers and facilitators.

Acute medicine·2026

Same journal

What does a job in Acute Medicine look like? Insights from the RCP 2023 Workforce Census.

Acute medicine·2026

Same journal

Embedding penicillin de-labelling in the AMU: a feasibility and safety pilot study with exploratory economic and environmental analysis.

Acute medicine·2026

Same journal

'Not All Swellings Are Angioedema' - An Overview And Systematic Approach For Acute Medical Physicians.

Acute medicine·2026

Same journal

The experiences of international medical graduates (IMGs) new to the NHS: an interpretive phenomenological analysis.

Acute medicine·2026

Same journal

Editorial - Differential attainment in training in the United Kingdom.

Acute medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 27, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Problem based review: The patient with hypercalcaemia.

P Machenahalli¹, K Shotliff²

¹ST6-Diabetes and Endocrinology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH.

|January 15, 2016

Summary

This summary is machine-generated.

Hypercalcaemia, often caused by primary hyperparathyroidism or malignancy, requires prompt assessment. Measuring parathyroid hormone (PTH) levels is crucial for diagnosis and guiding management, including medical options like Cinacalcet.

More Related Videos

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

Related Experiment Videos

Last Updated: Mar 27, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

Area of Science:

Endocrinology
Internal Medicine
Nephrology

Background:

Hypercalcaemia is a frequent presentation in Acute Medical Units.
Primary hyperparathyroidism (PHPT) and malignancy are the predominant causes, representing over 90% of cases.
Accurate diagnosis is essential for appropriate patient management.

Purpose of the Study:

To outline the diagnostic approach to hypercalcaemia.
To emphasize the role of parathyroid hormone (PTH) assessment.
To highlight medical management strategies for PHPT.

Main Methods:

Systematic clinical assessment.
Adequate patient rehydration.
Measurement of parathyroid hormone (PTH) levels.

Main Results:

Assessment of PTH levels differentiates parathyroid-mediated hypercalcaemia.
Systematic evaluation and rehydration facilitate diagnosis.
Medical management with Cinacalcet is effective for non-surgical PHPT.

Conclusions:

Prompt and systematic assessment, including PTH measurement, is vital for diagnosing hypercalcaemia.
Adequate hydration is a key initial step.
Cinacalcet offers a medical management option for primary hyperparathyroidism unsuitable for surgery.