Abnormal Amygdala Resting-State Functional Connectivity in Irritable Bowel Syndrome
AJNR. American Journal of Neuroradiology
|January 16, 2016
Summary
Patients with irritable bowel syndrome exhibit altered amygdala functional connectivity, impacting emotional and visceral processing. These brain network changes are linked to symptom severity and pain intensity in IBS.
Area of Science:
- Neuroscience
- Gastroenterology
- Medical Imaging
Background:
- Irritable bowel syndrome (IBS) is associated with corticolimbic region abnormalities.
- Hyperactivity of the amygdala during stimulation is a known finding in IBS.
Purpose of the Study:
- To investigate alterations in amygdala neural circuitry in IBS patients.
- To examine resting-state functional connectivity (rsFC) of the amygdala in IBS.
Main Methods:
- Functional magnetic resonance imaging (fMRI) data acquired from 31 IBS patients and 32 healthy controls at rest.
- Comparison of bilateral amygdala rsFC between groups.
- Multiple regression analysis to correlate rsFC with clinical IBS indices.
Main Results:
- IBS patients showed higher amygdala rsFC with the insula, midbrain, parahippocampal gyrus, pre/postcentral gyri, and supplementary motor area compared to controls.
- These differences persisted after accounting for anxiety and depression.
- Pain intensity correlated with amygdala rsFC to the supplementary motor area, pre/postcentral gyri, and insula.
- IBS Symptom Severity Score correlated with amygdala rsFC to the insula and midbrain.
Conclusions:
- IBS patients exhibit disturbed amygdala rsFC with corticolimbic regions.
- These connectivity changes may explain heightened emotional arousal and visceral processing in IBS.
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