Related Experiment Video
Updated: Mar 27, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Natural Product-Based Antibiotics: Synthesis and SAR-Studies
1Helmholtz Zentrum für Infektionsforschung, Braunschweig, Germany. evgeny.prusov@helmholtz-hzi.de.
Abstract:
Efficient control of the infectious diseases in the era of the emerging bacterial resistance demands consistent development of new antibiotic agents with novel modes of action. With some notable exceptions, the majority of the currently used antibiotics are natural product-derived compounds which were elaborated upon lead structures discovered by screening of various isolates. In this review, we summarized some selected examples of recent advances in the area of natural product based antibiotic development with particular emphasis on the synthetic and SAR-elucidation aspects.
More Related Videos
10:49Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
10:41The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
Published on: January 13, 2013
Related Concept Videos
Production of Antibiotics
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Inhibitors of Gram-positive Cell Wall Synthesis
Antibiotic Selection
Peptidoglycan Synthesis