Correlation analysis between serum lipoprotein (a) and the incidence of aortic valve sclerosis

This clinical trial explores the correlation between serum lipoprotein and the severity of aortic valve sclerosis in patients diagnosed with aortic valve sclerosis (AVS). A total of 1260 subjects diagnosed with AVS were enrolled in this study between May 2005 and June 2013 and divided into the young-aged (30-59 years, n=217), middle-aged (60-74 years, n=561) and elderly groups (75-93 years, n=482). In each group, patients were sub-grouped into AVS and healthy controls according to angiography findings. Parameters including triglyceride (TG), serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), free fatty acid (FFA), lipoprotein (a) [Lp(a)], apolipoprotein A1 (ApoAl) and apolipoprotein B (ApoB) were accurately measured. Correlation between these parameters and the severity of AVS was statistically evaluated. In the middle-aged and elderly groups, serum Lp(a), TC and LDL-C were significantly higher in patients with AVS compared with healthy counterparts (both P<0.05). In the elderly group, serum HDL-C in AVS patients was significantly lower than healthy subjects (P<0.05). In the young-aged group, serum Lp(a) and ApoB were significantly increased compared with healthy counterparts (both P<0.05). Gemini score in the elderly group was significantly higher than the other groups (both P<0.01). No statistical significance was observed in Lp(a) levels among groups I, II and III. The number of coronary stenosis in group III was significantly increased than those in groups I and II (P<0.01). Lp(a), LDL-C and aging act as independent risk factors of AVS and promote the incidence and progress of AVS.