Reducing Medication Administration Errors in Acute and Critical Care: Multifaceted Pilot Program Targeting RN Awareness and Behaviors
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Updated: Mar 27, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Marianne L Durham1, Rosemarie Suhayda, Patricia Normand
1Author Affiliations: Clinical Assistant Professor (Dr Durham), Health Systems Science, College of Nursing, University of Illinois at Chicago; Director (Dr Normand), Department of Preventative Medicine, Mindful Life Program; and Medication Safety Pharmacist (Dr Jankiewicz), Rush University Medical Center; Associate (Dr Suhayda), Provost Institutional Research, Assessment and Accreditation, and Director of Evaluation and Associate Professor, College of Nursing, Rush University; and Associate Professor (Dr Fogg), College of Nursing and Department of Psychology, Rush University, Chicago, Illinois.
Objective:
The aim of this medication safety pilot program was to increase RN sensitivity to potential error risk, improve behaviors, and reduce observed medication administration errors (MAEs).
Background:
MAEs are common and preventable and may lead to adverse drug events, costing the patient and organization. MAEs are low visibility, rarely intercepted, and underreported.
Methods:
An interprofessional team used process improvement methodology to develop a human factors-based medication safety pilot program to address identified issues. An observational time-series design study monitored the effect of the program.
Results:
After the program, error interception practices during administration increased, and some nurses reported using a mindfulness strategy to gain situational awareness before administration. Process behaviors were performed more consistently, and the risk of MAE decreased. Familiarity and complexity were identified as additional variables affecting MAE outcome.
Conclusions:
Strategies to support safe medication administration may reduce error and be of interest to nurse leaders.
Insights
A pilot program enhanced nurse awareness and practices, leading to fewer medication administration errors (MAEs). This initiative improved safety behaviors and reduced the risk of adverse drug events.
Area of Science:
- Nursing Practice
- Patient Safety
- Human Factors Engineering
Background:
- Medication administration errors (MAEs) are frequent, preventable, and contribute to adverse drug events.
- MAEs often go unnoticed, intercepted, or reported, highlighting a critical gap in patient safety.
- The financial and patient-related costs of MAEs necessitate targeted safety interventions.
Purpose of the Study:
- To implement a pilot program aimed at increasing registered nurse (RN) recognition of medication error risks.
- To enhance RN behaviors associated with safe medication administration.
- To decrease the incidence of observed medication administration errors (MAEs).
Main Methods:
- Utilized process improvement methodologies and human factors principles to design the intervention.
- Employed an observational time-series study design to evaluate the program's impact.
- Focused on an interprofessional team approach to medication safety.
Main Results:
- Observed an increase in error interception practices during medication administration.
- Nurses reported adopting mindfulness strategies for improved situational awareness.
- Demonstrated more consistent performance of safe medication administration process behaviors.
- Found a reduced risk of medication administration errors (MAEs).
- Identified familiarity and complexity as factors influencing MAE outcomes.
Conclusions:
- The developed strategies effectively support safe medication administration.
- The pilot program shows potential for reducing medication errors.
- Findings are relevant for nurse leaders focused on enhancing medication safety.
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