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Drug development from the bench to the pharmacy: with special reference to dipeptidyl peptidase-4 inhibitor

R D Carr1

  • 1MSD A/S, Copenhagen V, Denmark.

Diabetic Medicine : a Journal of the British Diabetic Association
|January 17, 2016
PubMed

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Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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