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Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination

Yi-Nan Zhang1, Wilson Poon1, Anthony J Tavares1

  • 1Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 18, 2016
PubMed
Summary

Most administered nanoparticles accumulate in the liver, reducing therapeutic efficacy and increasing toxicity. This review explores nanoparticle-liver interactions and strategies to overcome liver sequestration for improved nanomedicine translation.

Keywords:
Hepatobiliary clearanceLiverMacrophageNanoparticle

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