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Related Experiment Videos

Primary central nervous system lymphoma.

B P O'Neill1, J J Illig

  • 1Department of Neurology, Mayo Clinic, Rochester, MN 55905.

Mayo Clinic Proceedings
|August 1, 1989
PubMed
Summary
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Primary central nervous system lymphomas are rare brain tumors often linked to immunosuppression. Conventional treatments offer a grim prognosis, with survival rates below 5% at five years.

Area of Science:

  • Neuro-oncology
  • Immunology

Background:

  • Primary central nervous system lymphomas (PCNSL) are rare, comprising <2% of primary brain tumors.
  • Often associated with immunosuppression, PCNSL typically affects middle-aged men presenting with subacute mass lesion symptoms.

Purpose of the Study:

  • To summarize the characteristics, diagnosis, treatment, and prognosis of primary central nervous system lymphomas.

Main Methods:

  • Review of computed tomography (CT) findings.
  • Histopathological classification (predominantly B-cell lymphomas).
  • Analysis of treatment outcomes with conventional therapy (whole-brain irradiation +/- chemotherapy).

Main Results:

  • PCNSL often presents as a single, bulky mass, but multiple lesions occur in ~25% of cases.

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  • CT findings are distinctive; the majority are aggressive B-cell lymphomas.
  • Surgical intervention is primarily for diagnosis, not curative removal.
  • Conventional therapy yields a median survival <2 years and a 5-year survival <5%.

    • Conclusions:

    • Primary CNS lymphomas have a poor prognosis despite distinctive imaging features.
    • Current conventional therapies, including radiation and chemotherapy, show limited efficacy.
    • Further research into novel therapeutic strategies is warranted for this aggressive malignancy.