Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

756
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
756
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

2.4K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
2.4K
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

3.3K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
3.3K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

651
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
651
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

1.1K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.1K
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

1.0K
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association Between Circadian Onset Time and Clinical Outcomes in Acute Ischemic Stroke.

Noro psikiyatri arsivi·2026
Same author

Is FIB-4 Index an Independent Risk Factor for Hematoma Expansion in Acute Intracerebral Hemorrhage? A Retrospective Multicenter Observational Cohort Study.

Journal of clinical medicine·2026
Same author

Neurogenic bowel dysfunction in multiple sclerosis: clinical determinants and its association with bladder dysfunction in a multicenter study.

Archives of physical medicine and rehabilitation·2026
Same author

Hashimoto's encephalopathy in psychiatric inpatients: neuropsychiatric morbidity, diagnostic challenges and treatment.

Frontiers in psychiatry·2025
Same author

Retrospective chart review of cases of steroid-responsive catatonia: exploring a potential autoimmune aetiology.

BJPsych open·2025
Same author

Paraneoplastic bilateral vocal cord paralysis in a patient with anti-Hu syndrome after receiving nivolumab: Case report and literature review.

Journal of neuroimmunology·2025

Related Experiment Video

Updated: Mar 27, 2026

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

14.3K

Restless legs syndrome in multiple sclerosis.

Mine Hayriye Sorgun, Zerin Aksun, Yahya Burak Atalay

    Turkish Journal of Medical Sciences
    |January 19, 2016
    PubMed
    Summary

    Restless Legs Syndrome (RLS) is more prevalent in patients with Multiple Sclerosis (MS). However, RLS onset in MS patients showed no significant link to functional system involvement or disease progression.

    Area of Science:

    • Neurology
    • Sleep Medicine

    Background:

    • Conflicting literature exists on the relationship between functional system involvement, Expanded Disability Status Scale (EDSS), and Restless Legs Syndrome (RLS) in Multiple Sclerosis (MS) patients.
    • Understanding this association is crucial for managing MS symptoms and improving patient quality of life.

    Purpose of the Study:

    • To investigate the prevalence of RLS in MS patients compared to a control group.
    • To determine if there is a relationship between RLS and functional system involvement in MS patients.

    Main Methods:

    • A study involving 91 MS patients and 40 controls (headache, essential tremor, benign positional paroxysmal vertigo).
    • Neurological examinations and Kurtzke functional system scores were performed.
    • Semistructured interviews with a questionnaire assessed RLS onset relative to MS onset.

    More Related Videos

    Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
    06:19

    Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

    Published on: September 9, 2022

    4.8K
    Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study
    08:40

    Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study

    Published on: November 11, 2022

    1.5K

    Related Experiment Videos

    Last Updated: Mar 27, 2026

    Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
    14:55

    Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

    Published on: April 18, 2011

    14.3K
    Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
    06:19

    Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

    Published on: September 9, 2022

    4.8K
    Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study
    08:40

    Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study

    Published on: November 11, 2022

    1.5K

    Main Results:

    • RLS prevalence was significantly higher in MS patients (17.6%) than in controls (2.5%) (P = 0.018).
    • All RLS cases in MS patients emerged after MS onset; none preceded it.
    • No significant association was found between functional system involvement and RLS presence in MS patients.

    Conclusions:

    • RLS is more common in individuals with MS compared to the general population.
    • RLS in MS patients does not appear to be linked to the degree of neurological impairment or disability progression.