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Updated: Jul 15, 2026
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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Association Between Circadian Onset Time and Clinical Outcomes in Acute Ischemic Stroke
Nijat Abbaszade1, Mine Hayriye Sorgun1, Umut Bozkurt1
1Department of Neurology, Ankara University School of Medicine, İbni Sina Hospital, Ankara, Türkiye.
Noro Psikiyatri Arsivi
|July 14, 2026
Summary
Patients experiencing ischemic stroke during sleep were less likely to receive intravenous thrombolysis (IV tPA). However, stroke onset time did not significantly affect patient prognosis or mortality outcomes.
Area of Science:
- Neurology
- Circadian Biology
- Vascular Medicine
Background:
- Circadian rhythms are known to influence the onset of ischemic stroke.
- The impact of circadian timing on stroke treatment and outcomes is not well understood.
Purpose of the Study:
- To investigate the association between the circadian timing of ischemic stroke onset and patient vascular risk profiles.
- To analyze the relationship between stroke onset time and stroke severity, prognosis, and treatment strategies.
Main Methods:
- Retrospective review of 751 acute ischemic stroke patients admitted between August 2017 and December 2023.
- Patients were categorized into four groups based on stroke onset time.
- Data collected included demographics, clinical characteristics, intravenous thrombolysis (IV tPA), thrombectomy, and modified Rankin Scale (mRS) scores.
Main Results:
- Ischemic stroke occurring during sleep (Group 1) was associated with significantly lower rates of IV tPA administration (p <0.001).
- Higher National Institutes of Health Stroke Scale (NIHSS) scores and stroke onset time were independent predictors of IV tPA administration.
- Hypertension prevalence was lower in the 12:00-18:00 onset group (p=0.0027).
Conclusions:
- Ischemic stroke patients experiencing onset during sleep receive IV tPA less frequently, suggesting a need for improved detection methods.
- Despite differing IV tPA administration rates, stroke onset time did not significantly impact overall patient prognosis, including mortality and functional outcomes.
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