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Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow

O Garraud1, F Heshmati2, B Pozzetto3

  • 1Faculté de médecine de Saint-Étienne, université de Lyon, 42023 Saint-Étienne, France; Institut national de la transfusion sanguine, 75015 Paris, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|January 19, 2016
PubMed

Plasma therapy consists in bringing to a patient in need - in general suffering a severe, resistant to current therapy, and even lethal infection - plasma or specific, fractioned, antibodies, along with other immunoglobulins and possibly healing factors that can be obtained from immunized blood donors; donors (voluntary and benevolent) can be either actively immunized individuals or convalescent persons. Plasma therapy has been used since the Spanish flu in 1917-1918, and regularly then when viral epidemics threatened vulnerable populations, the last reported occurrence being the 2013-2015 Ebola virus outbreak in West Africa. The precise action mechanism of plasma therapy is not fully delineated as it may function beyond purified, neutralizing antibodies.

Keywords:
Anticorps neutralisantsConvalescent plasmaEbolavirusEbolavirus infectionInfectious diseaseMaladies infectieusesNeutralizing antibodiesPlasma convalescentPlasma therapyPlasma thérapeutiquePlasmathérapieTherapeutic plasmaTransfusion

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