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Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
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Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Related Experiment Video

Updated: Mar 27, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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[Negative symptoms and cerebral imaging].

A Kaladjian1, R Belzeaux2, M Adida2

  • 1Pôle de Psychiatrie des adultes, CHU Robert Debré, Avenue du Général Koenig, 51092 Reims cedex, France.

L'Encephale
|January 19, 2016
PubMed
Summary

Brain imaging reveals structural and functional abnormalities linked to schizophrenia

Keywords:
Negative symptomsNeuroimagerieNeuroimagingSchizophreniaSchizophrénieSymptômes négatifs

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Schizophrenia presents with neuroanatomical and neurofunctional abnormalities.
  • Brain correlates of negative symptoms in schizophrenia remain poorly understood.

Purpose of the Study:

  • To review brain imaging studies assessing cerebral correlates of negative symptoms in schizophrenia.
  • To identify specific structural and functional brain abnormalities associated with negative symptoms.

Main Methods:

  • Review of selected neuroimaging studies (structural and functional).
  • Analysis of findings from gray matter density, cortical thickness, white matter integrity, and neurofunctional imaging (PET).

Main Results:

  • Structural abnormalities include reduced gray matter density/cortical thickness in frontal and temporal regions (medial frontal, orbitofrontal, amygdalo-hippocampic complex).
  • White matter integrity deficits observed in frontal-limbic pathways.
  • Functional abnormalities involve frontal areas and limbic striatum, suggesting fronto-striatal loop dysfunction and striatal dopaminergic deficit.

Conclusions:

  • Negative symptoms of schizophrenia may be explained by fronto-striatal loop dysfunction and dopaminergic deficits.
  • Further research into lateralization and disease progression of these abnormalities could inform new therapeutic strategies.
  • Targeting these brain abnormalities may offer novel treatment options for treatment-resistant negative symptoms.