[The connotation and application thoughts of brain-reproductive medicine]

Neuroscience is a scientific discipline that meticulously dissects the architecture and functionality of the brain, as well as the physiological and pathological mechanisms of the nervous system. Reproductive medicine, on the other hand, is a specialized field that concentrates on scrutinizing the physiological and pathological processes within the male and female reproductive systems. The brain and the reproductive system are reciprocally intertwined in both structural and functional aspects, synergistically sustaining human growth, development, and procreation. Their relationship is conventionally encapsulated and explicated by the hypothalamus-pituitary-gonadal (HPG) axis. However, additional nexuses independent of this axis also prevail between the brain and the reproductive system.In the female context, the brain exerts its modulatory influence on reproductive function through neurotransmitter-mediated signaling and neurotrophic factor-dependent pathways. Reproductive hormones, in turn, can modulate neurotrophic factors to confer neuroprotection and perturb cerebral hemodynamics and white matter integrity. In the male counterpart, the brain impacts reproductive function via neurotransmitter-mediated transduction, and its anatomical conformation can directly impinge on male reproductive capabilities. Reproductive hormones can also influence the brain by means of antioxidant stress mitigation and anti-inflammatory responses.The aggregate of these brain-reproductive interaction mechanisms, in conjunction with the HPG axis, delineate the highly convoluted and multifaceted relationship between the brain and the reproductive system. Grounded on the cutting-edge research and oriented towards theoretical deliberations and clinical exigencies, the concept of "brain reproductive medicine" is cogently postulated. This concept zeroes in on the exploration of the complex relationship between the brain and reproduction, serving as a referential framework for disciplinary progression and academic interchange, augmenting the profundity of understanding regarding the brain-reproductive system relationship, and potentiating the caliber of multidisciplinary therapeutics for affiliated maladies.