Androgens are a Key Factor Affecting Immune Related Diseases

Area of Science:

• Immunology
• Endocrinology
• Reproductive Biology

Background:

• Androgens exhibit immunosuppressive effects, impacting immune disease outcomes differently in males and females.
• The precise mechanisms underlying androgen-mediated immune modulation remain largely undetermined.
• Understanding these mechanisms is crucial for addressing sex-based disparities in immune-related diseases.

Purpose of the Study:

• To analyze trends and identify key topics in the interdisciplinary field of androgen and immunology over the past decade.
• To elucidate the relationship between androgens, immune function, and specific diseases.

Main Methods:

• Bibliometric analysis of scientific literature.
• Literature search conducted in the Web of Science Core Collection (WoSCC) database.
• Focus on publications from the last ten years.

Main Results:

• Identified prostate cancer, triple-negative breast cancer, and sex differences in respiratory diseases as prominent research areas.
• Highlighted the significant role of male reproductive organs (testes) in androgen synthesis and immune function.
• Revealed a connection between male reproduction and immune system regulation.

Conclusions:

• Androgen-immunology interactions are complex, with significant implications for sex-specific disease progression.
• Male reproductive health is intrinsically linked to immune function, offering novel therapeutic perspectives.
• Further research into androgen's role can inform targeted strategies for immune disease prevention and treatment.