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Related Experiment Video

Updated: Mar 27, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
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Longitudinal changes in developmental defects of enamel.

Hai Ming Wong1, Yi Feng Wen1, Nigel Martyn King2

  • 1Paediatric Dentistry & Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong.

Community Dentistry and Oral Epidemiology
|January 19, 2016
PubMed
Summary
This summary is machine-generated.

Developmental defects of enamel (DDE) prevalence significantly decreased over three years, primarily due to a reduction in diffuse opacities. This study tracked DDE changes in participants from age 12 to 15.

Keywords:
epidemiologyfluoride

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Area of Science:

  • Dental Public Health
  • Pediatric Dentistry
  • Epidemiology

Background:

  • Developmental defects of enamel (DDE) are common dental findings.
  • Limited longitudinal data exists on DDE epidemiological changes over time.
  • Understanding DDE's natural progression is crucial for public health interventions.

Purpose of the Study:

  • To investigate longitudinal changes in the prevalence and severity of DDE.
  • To determine if DDE characteristics evolve with age.
  • To identify specific DDE types contributing to observed changes.

Main Methods:

  • A cohort of 432 participants aged 12 were re-examined at age 15.
  • Index teeth (incisors and first molars) were assessed using the modified FDI (DDE) Index.
  • Examinations were conducted by trained and calibrated professionals.

Main Results:

  • Overall DDE prevalence significantly decreased between ages 12 and 15 (P < 0.001).
  • This reduction was mainly driven by a significant decrease in diffuse opacities (P < 0.001).
  • The severity of diffuse opacities also significantly reduced over the study period (P < 0.0001).

Conclusions:

  • Diffuse opacities show a tendency to fade in prevalence and severity over time.
  • The overall decrease in DDE was predominantly influenced by changes in diffuse opacities.
  • Demarcated opacities and hypoplasia did not show a similar fading trend.