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Updated: Mar 27, 2026
Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
Published on: January 22, 2011
[Difficulties and limitations in conducting translational research in thoracic oncology. A practical example]
A-P Meert1, L Ameye2, N Leclercq1
1Service des soins intensifs, urgences oncologiques et oncologie thoracique, institut Jules-Bordet, université libre de Bruxelles, 1, rue Héger-Bordet, 1000 Bruxelles, Belgique.
Introduction:
In a first study, we identified signatures of 3 mRNAs (semaphorin 3D [SEMA3D], cytokeratin 16 [KRT16] and UL16 binding protein 2 [ULBP2]) associated to response to a cisplatin-vinorelbin chemotherapy and to survival of advanced non-small cell lung cancers (NSCLC).
Material And Methods:
The aim of this study was to develop immunohistochemistry tests for KRT16, ULBP2 and SEMA3D and to test proteins expression for prediction of response and survival in biopsies of the same patients.
Results:
We were not able to reproduce by the protein expression study the signature predicting response to chemotherapy in advanced NSCLC.
Conclusion:
We highlight the difficulties of translational research in thoracic oncology emphasizing the complexity in obtaining adequate tissue samples and the difficulties in conduction and transposing in routine practice high throughput technique for transcriptomic analyses.
