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Solanidine and tomatidine trigger scar pruritus
Pedro E Alonso1, Luis F Rioja1
1Department of Plastic Surgery, University Hospital Reina Sofía, Avda. Menéndez Pidal S/N, 14004 Córdoba, Spain.
Burns : Journal of the International Society for Burn Injuries
|January 19, 2016
Summary
Solanaceae alkaloids, like solanidine and tomatidine, trigger scar pruritus in most patients. Eliminating these nightshades can alleviate difficult-to-treat itching, especially after burns.
Area of Science:
- Dermatology
- Toxicology
- Clinical Medicine
Background:
- Scar pruritus is a common and challenging condition, particularly in burn survivors.
- Current treatments are often ineffective, and its pathogenesis remains unclear.
- Previous research suggested a solanaceae-free diet benefits patients with antihistamine-resistant scar pruritus.
Purpose of the Study:
- To investigate the hypothesis that solanaceae alkaloids are the pruritogens responsible for scar pruritus.
- To identify specific solanaceae aglycones that induce pruritus in affected patients.
Main Methods:
- A single-blind prospective study was conducted on 18 patients who improved on a solanaceae-free diet.
- Patients' scars were exposed to solanidine and tomatidine (solanaceae aglycones).
- The pruritogenic effect of each aglycone was assessed.
Main Results:
- 18 patients (90%) developed pruritus upon application of solanaceae aglycones.
- The specific aglycone that triggered itching corresponded to the suspected pruritogenic food (e.g., potato, tomato).
- This confirms a direct link between solanaceae aglycones and scar pruritus.
Conclusions:
- Solanaceae aglycones are directly implicated in the pathogenesis of scar pruritus.
- Identifying and avoiding specific solanaceae foods may be a viable treatment strategy.
- Further research into alkaloid-specific mechanisms is warranted.
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