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Published on: April 25, 2025
The first cases of human bacteremia caused by Acinetobacter seifertii in Japan
Kozue Kishii1, Ken Kikuchi2, Junko Tomida3
1Department of Medical Technology, School of Health Sciences, Tokyo University of Technology, Nishikamata, Ohta-ku, Tokyo 144-8535, Japan; Department of Infectious Disease, Tokyo Women's Medical University, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Abstract:
Acinetobacter seifertii, a novel species of Acinetobacter, was first reported in 2015. A. seifertii strains were isolated from human clinical specimens (blood, respiratory tract, and ulcer) and hospital environments. Here, we report the first cases of bacteremia caused by A. seifertii in patients with catheter-related bloodstream infection in Japan. The patients favorably recovered, without any complications, after removal of the peripheral intravenous catheters and administration of antibiotics. The pathogens were initially identified as Acinetobacter baumannii, using phenotypic methods and the MicroScan Walkaway System; however, rpoB gene sequence analysis indicated 99.54% similarity to A. seifertii. Moreover, antimicrobial susceptibility testing revealed that one of the strains was not susceptible to gentamicin and ceftazidime. Our report shows that Acinetobacter species other than A. baumannii can also cause nosocomial infections and that accurate methods for the identification of causative agents should be developed.
