Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.9K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.9K
MicroRNAs01:22

MicroRNAs

4.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

24.6K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
MicroRNAs01:22

MicroRNAs

12.0K
12.0K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.8K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.8K
Membrane Fluidity01:26

Membrane Fluidity

17.8K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
17.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Copper import via CTR1 supports the β3-Adrenergic thermogenic program.

Molecular metabolism·2026
Same author

Copper Import via CTR1 Supports the β3-Adrenergic Thermogenic Program.

bioRxiv : the preprint server for biology·2026
Same author

Distinct HIF1α and HIF2α functions control skeletal muscle metabolism and erythropoiesis.

The Journal of clinical investigation·2026
Same author

Copper deficiency disrupts OXPHOS and mitochondrial dynamics through MTCH2-dependent copper trafficking in skeletal muscle.

bioRxiv : the preprint server for biology·2025
Same author

Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling.

Cell reports·2025
Same author

A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing.

Journal of cachexia, sarcopenia and muscle·2025

Related Experiment Video

Updated: Mar 27, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

6.8K

miRNA and cholesterol homeostasis.

Tae-Il Jeon1, Timothy F Osborne2

  • 1Department of Animal Science, Chonnam National University, Gwangju 61186, South Korea.

Biochimica Et Biophysica Acta
|January 19, 2016
PubMed
Summary

MicroRNAs (miRNAs) are epigenetic regulators impacting lipid metabolism and related diseases. This review explores how transcription factors influence miRNA networks in cholesterol regulation.

Keywords:
Cholesterol metabolismMetabolic diseaseMicroRNATranscription factor

More Related Videos

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

14.2K

Related Experiment Videos

Last Updated: Mar 27, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

6.8K
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

14.2K

Area of Science:

  • Molecular Biology
  • Genetics
  • Metabolic Science

Background:

  • MicroRNAs (miRNAs) are epigenetic regulators influencing gene expression.
  • miRNAs play a systemic role in controlling lipid metabolism via complex gene regulatory networks.
  • Dysfunctional lipid metabolism, often linked to miRNAs, contributes to metabolic diseases.

Purpose of the Study:

  • To review recent advances in understanding lipid-sensing transcription factors.
  • To examine the regulation of miRNA gene networks by these factors.
  • To discuss miRNA expression and function in cholesterol metabolism.

Main Methods:

  • Literature review of recent scientific advances.
  • Analysis of studies on transcription factors and miRNA regulation.
  • Synthesis of information on miRNA roles in cholesterol homeostasis.

Main Results:

  • Lipid-sensing transcription factors significantly regulate miRNA gene networks.
  • miRNA expression and function are crucial for cholesterol metabolism.
  • Complex interactions exist between transcription factors, miRNAs, and lipid metabolism.

Conclusions:

  • miRNAs are key players in regulating lipid and cholesterol metabolism.
  • Understanding these regulatory networks offers insights into metabolic diseases.
  • Further research into miRNA-mediated pathways is warranted for therapeutic strategies.