Related Experiment Video
Updated: Mar 27, 2026

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
Published on: May 20, 2024
Cluster Analytic Detection of Biological Sex: A Second Look
Abstract:
Golden and Meehl (1980) conducted a simulation with MMPI items to determine the accuracy of six popular clustering methods in detecting biological sex. They concluded that the results were "poor to mediocre" and that clustering methods have limited potential for contributing to knowledge. Their conclusion is inconsistent with the prior Monte Carlo literature on cluster analysis. A second look at the Golden-Meehl results reveals satisfactory clustering performance when they used the better MMPI item sets. Using Ward's clustering method and vocational interest items, the Golden-Meehl design was replicated with conditions providing a firmer inferential base. The replication results matched the favorable Golden-Meehl trials. In general, the results showed that Ward's method performed well when clustering was done with the more appropriate items.
Related Concept Videos
The Ratio of X Chromosome to Autosomes
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Sex-linked Disorders
Sex Linked Disorders
X and Y Chromosomes
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
Evolutionary Relationships through Genome Comparisons

