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Related Experiment Videos

Efferent limb of the atrial receptor reflex decrease in plasma renin activity in anaesthetized dogs.

M J Drinkhill1, G Vacca, D A Mary

  • 1Department of Cardiovascular Studies, The University, Leeds.

Quarterly Journal of Experimental Physiology (Cambridge, England)
|July 1, 1989
PubMed
Summary

Stimulating atrial receptors decreases plasma renin activity via renal nerves. This study in dogs reveals the efferent pathway for this reflex, involving neural control of renin release.

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Area of Science:

  • Cardiovascular physiology
  • Renal physiology
  • Neuroendocrinology

Background:

  • Atrial receptors play a role in regulating cardiovascular and renal functions.
  • The reflex response to atrial receptor stimulation includes changes in heart rate, natriuresis, and plasma renin activity.
  • The specific efferent pathways mediating these responses, particularly the decrease in plasma renin activity, require elucidation.

Purpose of the Study:

  • To investigate the efferent limb of the reflex responsible for decreased plasma renin activity upon atrial receptor stimulation.
  • To determine the role of renal nerves in mediating this renin suppression.

Main Methods:

  • Experiments were conducted on anesthetized dogs.
  • Atrial receptors were stimulated using distensible balloons in the left pulmonary vein-atrial junction and atrial appendage.

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  • Responses were assessed in two groups: one with tachycardia and natriuresis blocked, and another subjected to renal denervation.

    • Main Results:

    • A diuretic response, accompanied by a decrease in plasma renin activity, was observed when tachycardia and natriuresis were blocked.
    • Renal denervation abolished the decrease in plasma renin activity.
    • These findings indicate that the efferent pathway involves the renal nerves.

    Conclusions:

    • The efferent limb of the reflex response leading to decreased plasma renin activity involves the renal nerves.
    • Neural regulation via renal nerves is crucial for modulating renin release in response to atrial receptor stimulation.