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Neurovascular Interactions in the Neurologically Compromised Neonatal Brain

H Singh1,2, R Cooper3,4, C W Lee3,5

  • 1neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK. harsimrat.singh@ucl.ac.uk.

Advances in Experimental Medicine and Biology
|January 20, 2016
PubMed

Insights

Hypoxic ischaemic encephalopathy (HIE) in newborns can cause seizures and poor development. Simultaneous diffuse optical tomography (DOT) and electroencephalography (EEG) revealed key neurovascular changes during seizures in HIE neonates.

Area of Science:

  • Neonatal neurology
  • Neuroscience
  • Biomedical engineering

Background:

  • Neurological brain injuries like hypoxic ischaemic encephalopathy (HIE) and seizures are linked to adverse developmental outcomes in neonates.
  • Limited understanding of the neurological and cerebrovascular mechanisms of seizures hinders diagnosis and treatment.
  • Diffuse optical tomography (DOT) offers insights into haemodynamic changes (deoxygenated/oxygenated hemoglobin) crucial for understanding seizures and neurovascular coupling.

Purpose of the Study:

  • To investigate the neurovascular processes underlying seizures in neonates with HIE.
  • To explore the utility of simultaneous electroencephalography (EEG) and DOT for studying neonatal seizures.
  • To analyze the temporal correlation between electrographic seizures and haemodynamic changes.

Main Methods:

  • Simultaneous recording of electroencephalography (EEG) and diffuse optical tomography (DOT) data.
  • Acquisition of DOT-EEG data from two neonates diagnosed with HIE.
  • Analysis of haemodynamic changes (de/oxygenated hemoglobin concentrations) in relation to electrographic seizure activity.

Main Results:

  • Distinct haemodynamic changes were observed using DOT.
  • These haemodynamic changes were temporally correlated with electrographic seizures detected by EEG.
  • The study successfully acquired mutually informative DOT-EEG data from HIE neonates.

Conclusions:

  • Simultaneous DOT-EEG is a valuable technique for studying neurovascular coupling in HIE neonates.
  • The findings provide insights into the haemodynamic changes associated with seizures in this population.
  • This approach can improve the understanding and potential management of seizures in neonatal HIE.

Keywords:
Burst suppressionDiffuse optical tomographyHypoxic–ischaemic encephalopathyNeonatal seizuresNeurovascular coupling

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