Related Experiment Video

Updated: Mar 27, 2026

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.3K

Hypertension and stroke: an appraisal of the evidence and implications for clinical management

Daniel T Lackland1, Jenifer H Voeks1, Andrea D Boan1

  • 1a Division of Translational Neuroscience and Population Studies, Department of Neurology , Medical University of South Carolina , Charleston , SC 29425 , USA.

Expert Review of Cardiovascular Therapy
|January 20, 2016
PubMed

Insights

Intensive blood pressure treatment significantly lowers stroke risk, especially for those with hypertension. While benefits are clear, further research is needed to refine stroke prevention guidelines.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Nephrology

Background:

  • Hypertension is a major risk factor for cardiovascular and renal diseases.
  • The link between high blood pressure and stroke risk is well-established.
  • Previous stroke prevention guidelines for hypertension management lacked clarity due to evidence limitations.

Purpose of the Study:

  • To assess the evidence for hypertension management in stroke risk reduction.
  • To evaluate the impact of The Systolic Blood Pressure Intervention Trial (SPRINT) on stroke prevention.
  • To identify remaining evidence gaps in managing hypertension for stroke prevention.

Main Methods:

  • Review and appraisal of clinical study results and randomized control trials.
  • Analysis of evidence concerning hypertension management strategies.
  • Consideration of stroke as a primary outcome in clinical trials.

Main Results:

  • Intensive hypertension treatment demonstrates clear benefits for stroke prevention.
  • Evidence supports the reduction of stroke risk through blood pressure management.
  • The Systolic Blood Pressure Intervention Trial (SPRINT) provides significant data on intensive treatment.

Conclusions:

  • Intense blood pressure management is beneficial for primary and secondary stroke prevention.
  • Despite clear benefits, further research is required to address existing evidence gaps.
  • Optimizing hypertension treatment remains crucial for reducing stroke incidence.

Keywords:
Hypertensionevidence-based gradingguidelinesstroketarget blood pressures

More Related Videos

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

18.8K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
711
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.8K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
1.2K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.4K
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
645
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
831