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Inotuzumab ozogamicin in the treatment of acute lymphoblastic leukemia

Jenny Dahl1, Kayleigh Marx1, Elias Jabbour1

  • 1a Department of Leukemia , U.T. M.D. Anderson Cancer Center , Houston , TX , USA.

Expert Review of Hematology
|January 20, 2016
PubMed

Over 90% of leukemic blasts in patients with acute lymphoblastic leukemia express the marker CD22. Inotuzumab ozogamicin (INO) is a CD22-directed humanized monoclonal antibody conjugated to the potent cytotoxin, calicheamicin, via an acid labile linker. INO has shown high rates of response in the treatment of relapsed and refractory (R/R) ALL in single-agent studies, with fewer adverse effects than traditional cytotoxic chemotherapy. Given this experience, studies are now being done to evaluate INO in combination with low-intensity chemotherapy as frontline treatment for older adults with ALL and patients with R/R disease. Herein we will discuss the use of INO in the treatment of acute lymphoblastic leukemia.

Keywords:
CD22Inotuzumabacute lymphoblastic leukemiarefractoryrelapsed

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