Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

1.7K
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
1.7K
Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
Pigmentation01:19

Pigmentation

4.9K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.9K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.1K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decoding Skin Aging Through Transcriptomic Clocks: Gene Expression Signatures, Associated Pathways, and Explainable AI.

Genes·2026
Same author

Natural Extracts in Skin Repair and Wound Healing: Phytochemical Mechanisms and Dermopharmaceutical Perspectives.

Molecules (Basel, Switzerland)·2026
Same author

Cutaneous Fungal Infections in Greek Competitive Swimmers: A Cross-Sectional, Self-Reported Study.

Journal of fungi (Basel, Switzerland)·2026
Same author

Hepatic Duct Foreign Body Mimicking Cholangiocarcinoma: Case Analysis, Diagnostic Challenges, and Literature Review.

Cureus·2026
Same author

From Skin to Brain: Key Genetic Mediators Associating Cutaneous Inflammation and Neurodegenerative Diseases.

Genes·2025
Same author

Common Superficial Bacterial Skin Infections Self-Reported by 1047 Greek Competitive Swimmers: A 2021 Retrospective Study.

Infectious disease reports·2025
Same journal

Management of Traumatic Penile Degloving Injury in a Resource-Constrained Setting: A Case Report and Literature Review.

Clinical case reports·2026
Same journal

Central Diabetes Insipidus and Brain Herniation Secondary to Cryptococcal Meningitis in a Dog.

Clinical case reports·2026
Same journal

Tirzepatide-Induced Functional Small Bowel Obstruction in a Surgically Naïve Patient: A Case Report.

Clinical case reports·2026
Same journal

Culture-Negative Infective Endocarditis due to <i>Neisseria bacilliformis</i>: A Rare Case With Multisystem Embolization and Diagnostic Utility of Microbial Cell-Free DNA Testing.

Clinical case reports·2026
Same journal

Management of Spontaneous Coronary Dissection Complicated by Cardiogenic Shock: A Case Report.

Clinical case reports·2026
Same journal

RETRACTION: A Rare Case of Chikungunya Encephalitis and its Management: A Case Report and Literature Review.

Clinical case reports·2026
See all related articles

Related Experiment Video

Updated: Mar 27, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.4K

Pigmented perianal macules.

Efstathios Rallis1, Panagiotis Tsibouris2

  • 1Department of Dermatology Veterans Administration Hospital Athens Greece.

Clinical Case Reports
|January 20, 2016
PubMed
Summary
This summary is machine-generated.

Primary mucosal melanoma is rare, with anorectal melanoma accounting for only 1% of anorectal cancers. This rare cancer predominantly affects women aged 40-60, presenting with rectal bleeding and poor prognosis.

Keywords:
Anorectalmelanomametastasis

More Related Videos

Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.7K
Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
09:35

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer

Published on: January 29, 2020

8.3K

Related Experiment Videos

Last Updated: Mar 27, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.4K
Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.7K
Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
09:35

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer

Published on: January 29, 2020

8.3K

Area of Science:

  • Oncology
  • Gastroenterology
  • Dermatology

Background:

  • Primary mucosal melanoma is a rare malignancy, constituting less than 2% of all melanoma cases.
  • Anorectal melanoma is exceptionally rare, representing approximately 1% of all anorectal carcinomas.

Purpose of the Study:

  • To summarize the epidemiology, clinical presentation, and prognosis of primary anorectal melanoma.
  • To highlight the rarity and diagnostic challenges associated with this specific melanoma subtype.

Main Methods:

  • Literature review of primary anorectal melanoma cases.
  • Analysis of epidemiological data and clinical manifestations.
  • Review of treatment outcomes and prognostic factors.

Main Results:

  • Primary anorectal melanoma predominantly affects women.
  • The typical age of onset is between the 4th and 6th decades of life.
  • Common symptoms include rectal bleeding and tenesmus, often leading to delayed diagnosis.

Conclusions:

  • Primary anorectal melanoma is a rare and aggressive malignancy with a poor prognosis.
  • Early diagnosis is crucial but often challenging due to non-specific symptoms.
  • Further research is needed to improve understanding and therapeutic strategies for anorectal melanoma.