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[Current aspects in organ transplantation].

B Ryffel

    Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis
    |September 12, 1989
    PubMed
    Summary

    Immunosuppressive therapy has evolved from broad agents like azathioprine to targeted drugs such as cyclosporine, significantly improving organ transplant outcomes. Cyclosporine inhibits interleukin-2 production, marking a new era in immunomodulation for transplant patients.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Transplant Medicine

    Context:

    • Review of historical immunosuppressive therapies including azathioprine and steroids.
    • Introduction of selective immunosuppressants like cyclosporine and monoclonal antibodies.
    • Shift towards immunomodulation in transplantation.

    Purpose:

    • To review the history and evolution of immunosuppressive therapy in transplantation.
    • To summarize experimental data on cyclosporine's mechanism of action.
    • To discuss the impact of immunomodulatory agents on solid organ transplants.

    Summary:

    • Classical immunosuppression involved azathioprine and steroids.
    • Cyclosporine and monoclonal antibodies represent a new era of selective immunosuppression.
    • Cyclosporine inhibits interleukin-2 production and receptor formation, potentially via cyclophilin binding.
    • Immunomodulatory agents, particularly cyclosporine, have a substantial impact on solid organ transplants, though tolerance is not achieved.

    Impact:

    • Significant improvements in solid organ transplant outcomes due to immunomodulatory agents.
    • Cyclosporine's molecular mechanism offers insights into targeted immunosuppression.
    • Ongoing experimental drug development in pharmaceutical research continues to advance transplant therapies.

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