Protein corona: Opportunities and challenges
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Updated: Mar 27, 2026

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection
Published on: December 19, 2025
Saeid Zanganeh1, Ryan Spitler1, Mohsen Erfanzadeh2
1Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, CA, USA.
Abstract:
In contact with biological fluids diverse type of biomolecules (e.g., proteins) adsorb onto nanoparticles forming protein corona. Surface properties of the coated nanoparticles, in terms of type and amount of associated proteins, dictate their interactions with biological systems and thus biological fate, therapeutic efficiency and toxicity. In this perspective, we will focus on the recent advances and pitfalls in the protein corona field.
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