Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pregnancy and leukemia.

M A Caligiuri1, R J Mayer

  • 1Dana-Farber Cancer Institute, Harvard Medical School, Boston 02115.

Seminars in Oncology
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

Leukemia treatment during pregnancy is possible, with chemotherapy generally safe after the first trimester. Careful patient-by-patient decisions are crucial for both maternal leukemia control and fetal well-being.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct Observation of Polaritonic Chemistry by Nuclear Magnetic Resonance Spectroscopy.

Angewandte Chemie (International ed. in English)·2024
Same author

Impact of KRAS<sup>G12</sup> mutations on survival with trifluridine/tipiracil plus bevacizumab in patients with refractory metastatic colorectal cancer: post hoc analysis of the phase III SUNLIGHT trial.

ESMO open·2024
Same author

Effect of KRAS codon 12 or 13 mutations on survival with trifluridine/tipiracil in pretreated metastatic colorectal cancer: a meta-analysis.

ESMO open·2022
Same author

Neutropenia and survival outcomes in metastatic colorectal cancer patients treated with trifluridine/tipiracil in the RECOURSE and J003 trials.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Alternative rib bone biopsy measurements to estimate changes in skeletal mineral reserves in cattle.

Animal : an international journal of animal bioscience·2018
Same author

Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia.

Leukemia·2017
Same journal

Steroid-induced tumor lysis syndrome in solid tumors: A case report and review of the literature.

Seminars in oncology·2026
Same journal

PSMA PET/CT staging in intermediate-risk prostate cancer: Toward risk-adapted implementation.

Seminars in oncology·2026
Same journal

Angiogenesis and the corresponding antiangiogenic therapy in gastroenteropancreatic neuroendocrine neoplasms.

Seminars in oncology·2026
Same journal

Post-translational regulation of steroidogenesis and its clinical relevance in hormone responsive cancers.

Seminars in oncology·2026
Same journal

Physics-informed machine learning for tumor microenvironment-responsive nanomedicine: Recent updates.

Seminars in oncology·2026
Same journal

Stoma-free precision sphincter-preserving surgery with J-pouch for metastatic low rectal neuroendocrine tumor.

Seminars in oncology·2026
See all related articles

Area of Science:

  • Oncology
  • Maternal-Fetal Medicine
  • Hematology

Background:

  • Increasing numbers of leukemia survivors necessitate understanding pregnancy impacts.
  • Concerns exist regarding leukemia treatment's effect on pregnancy and vice versa.

Purpose of the Study:

  • To review the safety and implications of leukemia treatment during pregnancy.
  • To guide management decisions for pregnant leukemia patients.

Main Methods:

  • Review of small, retrospective series and case reports.
  • Analysis of existing data on leukemia development and treatment during gestation.

Main Results:

  • Leukemia can occur during pregnancy; abortion is not mandatory.
  • Standard chemotherapy is safe in the second and third trimesters; antifolates should be avoided in the first.

Related Experiment Videos

  • Cytarabine and anthracycline treatments for AML are not linked to birth defects.
  • Pregnancy carries increased risks (placental injury, sepsis, premature birth) due to myelosuppression.
  • Offspring of mothers with leukemia appear to develop normally.

    • Conclusions:

    • Leukemia treatment during pregnancy requires individualized management plans.
    • Balancing maternal leukemia control and fetal viability is paramount.
    • Delivery timing and mode should be determined on a case-by-case basis.