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Anthelmintic drug resistance in the UK
1Parasitology Department, Central Veterinary Laboratory, New Haw, Weybridge.
The Veterinary Record
|August 12, 1989
Summary
Anthelmintic drug resistance is the ability of nematode parasites to survive medication. This heritable trait is increasing globally, leading to drug treatment failures in sheep and horses.
Area of Science:
- Veterinary Parasitology
- Molecular Biology
Background:
- Anthelmintic drug resistance (ADR) is a growing concern in livestock management.
- Heritable resistance genes are present in pathogenic nematodes affecting ruminants and horses.
- Intensive farming practices can accelerate the selection of resistant parasite genotypes.
Purpose of the Study:
- To discuss the incidence, diagnosis, epidemiology, and implications of anthelmintic resistance.
- To highlight the emergence of multiple drug-resistant strains worldwide.
- To report on increasing benzimidazole resistance in UK sheep and horse nematodes.
Main Methods:
- Literature review and synthesis of existing research on anthelmintic resistance.
- Analysis of epidemiological data on drug resistance patterns.
- Case study insights from UK investigations.
Main Results:
- Anthelmintic resistance is a heritable trait allowing nematodes to survive recommended drug doses.
- ADR is reported globally, with some regions experiencing multi-drug resistant strains.
- UK studies show rising resistance to benzimidazoles in sheep and horse nematodes.
Conclusions:
- Anthelmintic resistance poses a significant threat to effective parasite control in livestock.
- Understanding the epidemiology and diagnosis of ADR is crucial for management.
- Continued monitoring and strategic drug use are essential to mitigate resistance.