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Updated: Mar 26, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Baroreflex dysfunction in chronic kidney disease.

Manpreet Kaur¹, Dinu S Chandran¹, Ashok Kumar Jaryal¹

¹Manpreet Kaur, Dinu S Chandran, Ashok Kumar Jaryal, Kishore Kumar Deepak, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.

World Journal of Nephrology

|January 21, 2016

Summary

This summary is machine-generated.

Chronic kidney disease (CKD) patients experience significant cardiovascular issues due to vascular calcification, which impairs baroreflex sensitivity (BRS) and blood pressure (BP) regulation. This review explores BRS dysfunction in CKD, linking it to increased cardiovascular risks.

Keywords:

Baroreflex sensitivity Blood pressure variability Chronic kidney disease Large arterial compliance Vascular calcification

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Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

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Published on: October 2, 2020

Area of Science:

Nephrology
Cardiovascular Medicine
Physiology

Background:

Patients with chronic kidney disease (CKD) exhibit elevated cardiovascular mortality and morbidity.
Traditional and CKD-specific risk factors contribute to accelerated vascular calcification in these individuals.
Vascular calcification is linked to reduced arterial compliance, impaired baroreflex sensitivity (BRS), and consequently, increased blood pressure (BP) variability, hindering BP regulation.

Purpose of the Study:

To review the physiology of the baroreflex and methods for assessing its function.
To examine the determinants and prognostic significance of BRS assessment in CKD patients.
To synthesize current literature on BRS in CKD and elucidate the underlying pathophysiology of baroreflex dysfunction.

Main Methods:

Literature review of baroreflex physiology and function assessment.
Analysis of studies investigating BRS in chronic kidney disease populations.
Discussion of pathological mechanisms contributing to baroreflex impairment in CKD.

Main Results:

Baroreflex dysfunction, characterized by impaired BRS, is prevalent in CKD patients.
Vascular calcification and associated arterial stiffening are key contributors to baroreflex impairment.
Reduced BRS in CKD is associated with poorer BP control and increased cardiovascular risk.

Conclusions:

Baroreflex sensitivity is significantly impaired in patients with chronic kidney disease.
Understanding baroreflex dysfunction is crucial for managing cardiovascular complications in CKD.
Further research into therapeutic strategies targeting baroreflex function may improve outcomes for CKD patients.