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Tissue Patterning: Translating Design Principles from In Vivo to In Vitro
Alison P McGuigan1,2, Sahar Javaherian1
1Department of Chemical Engineering and Applied Chemistry and.
Annual Review of Biomedical Engineering
|January 21, 2016
Summary
Mimicking natural tissue architecture is difficult. This review explores how developmental patterning principles can guide tissue engineering for better cell organization and tissue regeneration.
Area of Science:
- Developmental Biology
- Tissue Engineering
- Biotechnology
Background:
- Recreating native tissue architecture is a major hurdle in tissue engineering.
- Complex tissues with multiple cell types pose significant organizational challenges.
- Embryonic developmental processes offer a model for achieving controlled cellular organization.
Purpose of the Study:
- To review in vivo tissue patterning principles.
- To assess progress in mimicking these principles ex vivo for tissue engineering.
- To highlight the role of developmental processes in guided tissue regeneration.
Main Methods:
- Review of established in vivo developmental biology literature.
- Analysis of current ex vivo tissue engineering strategies.
- Comparison of embryonic patterning mechanisms with tissue engineering approaches.
Main Results:
- Tissue patterning relies on spatially controlled gene induction for cell differentiation.
- Compartment boundaries are crucial for maintaining distinct cell populations and tissue integrity.
- Fundamental principles of morphogen-driven patterning and boundary formation are conserved.
Conclusions:
- Understanding embryonic patterning provides a framework for tissue engineering.
- Mimicking developmental processes can improve the organization of engineered tissues.
- Further research into ex vivo patterning is essential for advancing regenerative medicine.
