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Updated: Mar 26, 2026

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
Nemonoxacin has potent activity against gram-positive, but not gram-negative clinical isolates
1Department of Respiratory Diseases, Second Artillery General Hospital, Beijing 100088, People's Republic of China.
Objectives:
The aim of the current study was to analyze the susceptibility of gram-positive and -negative clinical isolates to a novel des-F(6)-quinolone (nemonoxacin) and other selected antimicrobial agents.
Materials And Methods:
Minimal inhibitory concentrations (MICs) were determined by the agar plate dilution method according to NCCLs.
Results:
Nemonoxacin exhibited greater antimicrobial activity than other quinolones, such as ciprofloxacin, levofloxacin, and moxifloxacin, and other antimicrobials when tested against selected gram-positive organisms. This non-fluorinated quinolone was especially active against streptococci and staphylococci, including multi-resistant Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). Compared with ciprofloxacin, levofloxacin, and moxifloxacin, and other antimicrobials, nemonoxacin was not highly active against all tested gram-negative clinical isolates, with an MIC90 of 8-32 μg/mL.
Conclusions:
Nemonoxacin has powerful antibacterial activity against gram-positive strains and has value in treating quinolone-resistant clinical isolates of MSSA, MRSA, and S. pneumoniae infections. Nemonoxacin should not be the first choice to treat gram-negative clinical isolate infections.
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