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Updated: Mar 26, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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[Phosphorus: a new cardiovascular risk factor?].

M Insalaco1, R Scuderi2, L Zanoli2

  • 1UOC Nefrologia e Dialisi, P.O. "San Giovanni di Dio", Agrigento.

La Clinica Terapeutica
|January 23, 2016
PubMed
Summary
This summary is machine-generated.

High serum phosphate levels, even within the normal range, increase cardiovascular risk and chronic kidney disease progression. Early detection and management of phosphorus metabolism disorders are crucial for preventing cardiovascular mortality.

Keywords:
Cardiovascular riskChronic kidney diseasePhosphorusRisk factor

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Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Disorders

Background:

  • Phosphorus is vital for metabolic processes.
  • Elevated serum phosphate levels are linked to cardiovascular disease in CKD and non-CKD patients.
  • Even high-normal phosphate levels pose a risk for cardiovascular mortality and CKD progression.

Purpose of the Study:

  • To highlight the clinical relevance of serum phosphate levels.
  • To emphasize the role of phosphate overload as a cardiovascular risk factor.
  • To propose early diagnosis and intervention for phosphorus metabolism disorders.

Main Methods:

  • Review of studies on phosphorus and cardiovascular risk.
  • Identification of biomarkers for phosphate overload (FGF23, Klotho, urinary fractional excretion of phosphate).
  • Discussion of dietary interventions and therapeutic strategies.

Main Results:

  • High serum phosphate is associated with cardiovascular disease and CKD progression.
  • Phosphate levels within the upper normal range are identified as a risk factor.
  • Early biomarkers can aid in diagnosing phosphate overload.

Conclusions:

  • Lowering serum phosphate may be a future therapeutic target for cardiovascular disease.
  • Early diagnosis and treatment of phosphorus metabolism disorders are essential to prevent end-organ damage.
  • Dietary restriction, phosphate binders, and calcitriol supplementation can positively influence the phosphate-regulatory axis.