[Tick-borne encefalitis - pathogenesis and -therapeutic approaches].

Area of Science:

• Neuroscience
• Virology
• Immunology

Background:

• Tick-borne encephalitis (TBE) is a serious neurological disease prevalent in Europe and Russia.
• The TBE virus (TBEV) can cause severe central nervous system (CNS) infections.
• Understanding TBEV pathogenesis is crucial for developing effective treatments.

Purpose of the Study:

• To review current knowledge on TBEV-host interactions.
• To elucidate mechanisms of neuronal injury and immune responses in the CNS during TBE.
• To discuss factors influencing TBE disease progression and outcomes.

Main Methods:

• Literature review of existing research on TBEV.
• Analysis of host-pathogen interactions.
• Examination of immunological and neuropathological data.

Main Results:

• TBEV infection involves complex interactions affecting neuronal function.
• Immune responses in the CNS can lead to immunopathology.
• Host factors significantly influence disease severity and prognosis.

Conclusions:

• Novel therapeutic approaches may involve targeting viral replication and modulating immune responses.
• Combined small molecule inhibitors and immunomodulatory agents show promise for TBE treatment.
• Minimizing CNS immunopathology is key to improving TBE outcomes.