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[Quantitative perfusion imaging in magnetic resonance imaging].

F G Zöllner1, T Gaa2, F Zimmer2

  • 1Computerunterstützte Klinische Medizin, Medizinische Fakultät Mannheim, Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland. frank.zoellner@medma.uni-heidelberg.de.

Der Radiologe
|January 23, 2016
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Summary

Magnetic resonance imaging (MRI) perfusion imaging offers advanced insights into tissue function. Broader clinical adoption requires standardized protocols for this valuable diagnostic tool.

Keywords:
Arterial spin labelingCapillary permeabilityDynamic contrast enhanced magnetic resonance imagingQuantitative perfusion imagingTissue perfusion

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Area of Science:

  • Radiology and Medical Imaging
  • Functional Neuroimaging
  • Cardiovascular Imaging

Background:

  • Magnetic resonance imaging (MRI) provides excellent non-invasive tissue contrast without ionizing radiation.
  • Advancements in MRI hardware and imaging techniques enable the assessment of tissue and organ functions.
  • Perfusion imaging, a functional MRI technique, quantifies tissue perfusion and capillary permeability using dynamic imaging data.

Purpose of the Study:

  • To review the principles and applications of MRI perfusion imaging.
  • To highlight the diagnostic and therapeutic monitoring potential of perfusion MRI.
  • To discuss the current limitations and future directions for the widespread implementation of MRI perfusion.

Main Methods:

  • Perfusion MRI techniques include arterial spin labeling (ASL) using endogenous tracers and dynamic contrast-enhanced (DCE) MRI with exogenous gadolinium-based contrast agents.
  • ASL utilizes magnetically labeled water protons in arterial blood.
  • DCE-MRI involves injecting a contrast agent to calculate hemodynamic parameters.

Main Results:

  • Perfusion MRI has demonstrated significant potential in medical diagnostics and therapy monitoring.
  • Current utilization of perfusion MRI is limited to specialized centers like university hospitals.
  • Widespread application of perfusion MRI has not yet been achieved.

Conclusions:

  • MRI perfusion is a valuable technique for assessing tissue hemodynamics and function.
  • Standardization efforts at European and international levels are crucial for broader availability.
  • Professional bodies are actively promoting the implementation of standardized MRI perfusion protocols.