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Updated: Mar 26, 2026

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
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Microscale Rockets and Picoliter Containers Engineered from Electrospun Polymeric Microtubes.

Amit Sitt1,2, Jana Soukupova3, David Miller1

  • 1Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|January 23, 2016
PubMed
Summary

Biodegradable polymer microtubes with functional inner walls were created. These microtubes can act as microrockets or transform into tiny containers when exposed to ultrasound.

Keywords:
biodegradable polymerscatalytic micromotorselectrospinningmicrocontainersmicrotubes

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Area of Science:

  • Biomaterials Engineering
  • Nanotechnology
  • Polymer Science

Background:

  • Core/shell microtubes offer unique properties for advanced applications.
  • Biodegradable polymers are crucial for biomedical and environmental sustainability.
  • Controlled surface functionalization is key to tailoring microscale device performance.

Purpose of the Study:

  • To fabricate chemically functional core/shell microtubes using biodegradable polymers.
  • To explore the transformation of these microtubes into functional microrockets and containers.
  • To investigate ultrasound-induced shape-shifting capabilities for novel applications.

Main Methods:

  • Coaxial electrospinning technique for fabricating core/shell microtubes.
  • Chemical functionalization of luminal walls for regioselective binding.
  • Immobilization of catalytic nanoparticles or enzymes.
  • Ultrasound exposure for inducing shape transformation.

Main Results:

  • Successfully fabricated chemically functional core/shell microtubes from biodegradable polymers.
  • Demonstrated regioselective chemical binding/adsorption within the microtubes.
  • Converted microtubes into bubble-propelled microrockets by attaching catalysts/enzymes.
  • Achieved ultrasound-induced shape shifting into picoliter-scale containers.

Conclusions:

  • Chemically functional biodegradable microtubes are versatile platforms.
  • These microtubes can be engineered into responsive microrockets and containers.
  • The developed technology holds potential for drug delivery, sensing, and micro-robotics.